dc.creator | Badano, Inés | |
dc.creator | Sanabria, Daiana Jimena | |
dc.creator | Tótaro, Roxana María | |
dc.creator | Rubinstein, Samara | |
dc.creator | Gili, Juan Antonio | |
dc.creator | Liotta, Domingo Javier | |
dc.creator | Picconi, María Alejandra | |
dc.creator | Campos, Rodolfo Héctor | |
dc.creator | Schurr, Theodore G. | |
dc.date.accessioned | 2023-01-26T13:48:22Z | |
dc.date.available | 2023-01-26T13:48:22Z | |
dc.date.issued | 2018-01-12 | |
dc.identifier.citation | Badano, I., Sanabria, D. J., Totaro, M. E., Rubinstein, S., Gili, J. A., Liotta, D. J.,... Schurr, T. G. (2018). Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina. Plos One. San Francisco, Estados Unidos : PLOS; 13(1), pp. 1-16. | es_AR |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | CCPI-CNyE-A-032 | |
dc.identifier.other | 6616 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12219/4336 | |
dc.description | Fil: Badano, Inés. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. | es_AR |
dc.description | Fil: Badano, Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico (Nordeste); Argentina. | es_AR |
dc.description | Fil: Sanabria, Daiana Jimena. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. | es_AR |
dc.description | Fil: Sanabria, Daiana Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico (Nordeste); Argentina. | es_AR |
dc.description | Fil: Tótaro, Roxana María. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. | es_AR |
dc.description | Fil: Rubinstein, Samara. Universidad de Pennsylvania. Departamento de Antropología; Estados Unidos. | es_AR |
dc.description | Fil: Gili, Juan Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". Dirección de Investigación. Laboratorio de Epidemiología Genética; Argentina. | es_AR |
dc.description | Fil: Liotta, Domingo Javier. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina. | es_AR |
dc.description | Fil: Picconi, María Alejandra. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán”. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio de Virus Oncogénicos; Argentina. | es_AR |
dc.description | Fil: Campos, Rodolfo Héctor. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. | es_AR |
dc.description | Fil: Schurr, Theodore G. Universidad de Pennsylvania. Departamento de Antropología; Estados Unidos. | es_AR |
dc.description.abstract | Background Misiones Province in northeastern Argentina is considered to be a region with a high prevalence of HPV infection and a high mortality rate due to cervical cancer. The reasons for this epidemiological trend are not completely understood. To gain insight into this problem, we explored the relationship between mitochondrial DNA (mtDNA) ancestry, HPV infection, and development of cervical lesions/cancer in women from the city of Posadas in Misiones Province.
Methods
Two hundred and sixty-one women, including 92 cases of patients diagnosed with cervical lesions and 169 controls, were analyzed. mtDNA ancestry was assessed through HVS1 sequencing, while the detection and typing of HPV infection was conducted through nested multiplex PCR analysis. Multivariate logistic regression was conducted with the resulting data to estimate the odds ratios (ORs) adjusted by socio-demographic variables.
Results
The study participants showed 68.6% Amerindian, 26.1% European and 5.3% African mtDNA ancestry, respectively. Multiple regression analysis showed that women with African mtDNAs were three times more likely to develop a cervical lesion than those with Native American or European mtDNAs [OR of 3.8 (1.2–11.5) for ancestry and OR of 3.5 (1.0–12.0) for L haplogroups], although the associated p values were not significant when tested under more complex multivariate models. HPV infection and the development of cervical lesions/cancer were significant for all tested models, with the highest OR values for HPV16 [OR of 24.2 (9.3–62.7)] and HPV-58 [OR of 19.0 (2.4–147.7)].
Conclusion
HPV infection remains a central risk factor for cervical cancer in the Posadas population. The potential role of African mtDNA ancestry opens a new avenue for future medical association studies in multiethnic populations, and will require further confirmation in large-scale studies. | en |
dc.format | application/pdf | |
dc.format.extent | 1.946 MB | |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science | en |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190966 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.subject | HPV infection | en |
dc.subject | Mitochondrial dna ancestry | en |
dc.subject | Cervical cáncer | en |
dc.subject | Posadas Misiones Argentina | es_AR |
dc.title | Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina | en |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |