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dc.creatorDidion, John P.
dc.creatorMorgan, Andrew P.
dc.creatorYadgary, Liran
dc.creatorBell, Timothy A.
dc.creatorMcMullan, Rachel C.
dc.creatorOrtiz de Solorzano, Lydia
dc.creatorBritton-Davidian, Janice
dc.creatorBult, Carol J.
dc.creatorCampbell, Karl J.
dc.creatorCastiglia, Riccardo
dc.creatorChing, Yung-Hao
dc.creatorChunco, Amanda J.
dc.creatorCrowley, James J.
dc.creatorChesler, Elissa J.
dc.creatorFörster, Daniel W.
dc.creatorFrench, John E.
dc.creatorGabriel, Sofia I.
dc.creatorGatti, Daniel M.
dc.creatorGarland, Theodore Jr
dc.creatorGiagia Athanasopoulou, Eva B.
dc.creatorGiménez, Mabel Dionisia
dc.creatorGrize, Sofia A.
dc.creatorGündüz, Islam
dc.creatorHolmes, Andrew
dc.creatorHauffe, Heidi Christine
dc.creatorHerman, Jeremy S.
dc.creatorHolt, James M.
dc.creatorKunjie, Hua
dc.creatorJolley, Wesley J.
dc.creatorLindholm, Anna K.
dc.creatorLópez-Fuster, María J.
dc.creatorMitsainas, George
dc.creatorMathias, Maria da Luz
dc.creatorMcMillan, Leonard
dc.creatorMorgado Ramalhinho, Maria da Graç̧a
dc.creatorRehermann, Barbara
dc.creatorRosshart, Stephan P.
dc.creatorSearle, Jeremy B.
dc.creatorShiao, Meng-Shin
dc.creatorSolano, Emanuela
dc.creatorSvenson, Karen L.
dc.creatorThomas-Laemont, Patricia
dc.creatorThreadgill, David W.
dc.creatorVentura, Jacint
dc.creatorWeinstock, George M.
dc.creatorPomp, Daniel
dc.creatorChurchill, Gary A.
dc.creatorPardo Manuel de Villena, Fernando
dc.date.accessioned2023-01-31T17:50:07Z
dc.date.available2023-01-31T17:50:07Z
dc.date.issued2016-02-15
dc.identifier.citationDidion, J. P., Morgan, A. P., Yadgary, L., Bell, T. A., McMullan, R. C., Ortiz de Solorzano, L.,... Pardo Manuel de Villena, F. (2016). R2d2 drives selfish sweeps in the house mouse. Molecular Biology and Evolution. Oxford, Reino Unido : Oxford University Press; 33 (6), pp. 1381-1395.es_AR
dc.identifier.issn1537-1719
dc.identifier.otherCCPI-CNyE-A-173
dc.identifier.other9966
dc.identifier.urihttps://hdl.handle.net/20.500.12219/4474
dc.descriptionFil: Didion, John P. Universidad de Carolina del Norte. Departamento de Genética; Estados Unidos.es_AR
dc.descriptionFil: Didion, John P. Universidad de Carolina del Norte. Centro Integral del Cáncer Lineberger; Estados Unidos.es_AR
dc.descriptionFil: Didion, John P. Universidad de Carolina del Norte. Centro de Ciencias del Genoma de Carolina; Estados Unidos.es_AR
dc.descriptionFil: Morgan, Andrew P. Universidad de Carolina del Norte. Departamento de Genética; Estados Unidos.es_AR
dc.descriptionFil: Morgan, Andrew P. Universidad de Carolina del Norte. Centro Integral del Cáncer Lineberger; Estados Unidos.es_AR
dc.descriptionFil: Morgan, Andrew P. Universidad de Carolina del Norte. Centro de Ciencias del Genoma de Carolina; Estados Unidos.es_AR
dc.descriptionFil: Yadgary, Liran. Universidad de Carolina del Norte. Departamento de Genética; Estados Unidos.es_AR
dc.descriptionFil: Yadgary, Liran. Universidad de Carolina del Norte. Centro Integral del Cáncer Lineberger; Estados Unidos.es_AR
dc.descriptionFil: Yadgary, Liran. Universidad de Carolina del Norte. Centro de Ciencias del Genoma de Carolina; Estados Unidos.es_AR
dc.descriptionFil: Bell, Timothy A. Universidad de Carolina del Norte. Departamento de Genética; Estados Unidos.es_AR
dc.descriptionFil: Bell, Timothy A. Universidad de Carolina del Norte. Centro Integral del Cáncer Lineberger; Estados Unidos.es_AR
dc.descriptionFil: Bell, Timothy A. Universidad de Carolina del Norte. Centro de Ciencias del Genoma de Carolina; Estados Unidos.es_AR
dc.descriptionFil: McMullan, Rachel C. Universidad de Carolina del Norte. Departamento de Genética; Estados Unidos.es_AR
dc.descriptionFil: McMullan, Rachel C. Universidad de Carolina del Norte. Centro Integral del Cáncer Lineberger; Estados Unidos.es_AR
dc.descriptionFil: McMullan, Rachel C. Universidad de Carolina del Norte. Centro de Ciencias del Genoma de Carolina; Estados Unidos.es_AR
dc.descriptionFil: Ortiz de Solorzano, Lydia. Universidad de Carolina del Norte. Departamento de Genética; Estados Unidos.es_AR
dc.descriptionFil: Ortiz de Solorzano, Lydia. Universidad de Carolina del Norte. Centro Integral del Cáncer Lineberger; Estados Unidos.es_AR
dc.descriptionFil: Ortiz de Solorzano, Lydia. Universidad de Carolina del Norte. Centro de Ciencias del Genoma de Carolina; Estados Unidos.es_AR
dc.descriptionFil: Britton-Davidian, Janice. Université de Montpellier. Instituto Des Sciences de L'evolution; Francia.es_AR
dc.description.abstractA selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether “selfish” genes are capable of fixation—thereby leaving signatures identical to classical selective sweeps—despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.en
dc.formatapplication/pdf
dc.format.extent953.9 KB
dc.language.isoengen
dc.publisherOxford University Pressen
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectR2d2en
dc.subjectMeiotic driveen
dc.subjectSelfish genesen
dc.subjectSelective sweepen
dc.subjectHouse mouseen
dc.titleR2d2 drives selfish sweeps in the house mouseen
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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