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dc.creatorMiranda, Rafael N.
dc.creatorXimenes, Raphael
dc.creatorGebretekle, Gebremedhin B.
dc.creatorBielecki, Joanna M.
dc.creatorSander, Beate
dc.date.accessioned2023-08-24T13:23:17Z
dc.date.available2023-08-24T13:23:17Z
dc.date.issued2020-07-01
dc.identifier.citationMiranda, R.N., Ximenes, R., Gebretekle, G. B., Bielecki, J. M. y Sander, B. (2020). Health-related quality of life in neurological disorders most commonly associated with zika-virus infection: a systematic review. Value Health. Paises Bajos : Elsevier, 23(7), pp. 969-976.es_AR
dc.identifier.other26024
dc.identifier.otherCCPI-CNyE-A-133
dc.identifier.urihttps://hdl.handle.net/20.500.12219/5077
dc.descriptionFil: Miranda, Rafael N. University Health Network; Canadá.es_AR
dc.descriptionFil: Ximenes, Raphael. University Health Network; Canadá.
dc.descriptionFil: Gebretekle, Gebremedhin B. University Health Network; Canadá.
dc.descriptionFil: Bielecki, Joanna M. University Health Network; Canadá.
dc.descriptionFil: Sander, Beate. University Health Network; Canadá.
dc.description.abstractObjectives: In this systematic review, we synthesize the current evidence on health-related quality of life (HRQoL) for the two of the most relevant outcomes of Zika virus infection in humans, microcephaly and Guillain-Barré Syndrome (GBS). Methods: We searched the following databases: MEDLINE, Embase, CINAHL, LILACS, WHO’s ICTRP clinical trials registries database and PROSPERO. Search terms included quality of life, microcephaly, and Guillain-Barré Syndrome. We included primary studies where HRQoL was quantitatively assessed for microcephaly and GBS using validated instruments. We used the Joanna Briggs Institute Critical Appraisal Tools to assess the risk of bias of individual studies. Results: From a total of 1,657 abstracts screened and 66 full texts reviewed, 21 studies met the eligibility criteria; one study for microcephaly and 20 for GBS. Adjusted disutilities for microcephaly compared to a normative childhood utility ranged from 20.745 to 20.820. For GBS, time traded-off the expected lifetime ranged from 16 days to 3 years. HRQoL follows the clinical course of GBS, with lower scores in the first months, recovery within the first year post onset, and stabilization after one year. Conclusions: Included studies reported a wide range of HRQoL for GBS, due in part to a high level of heterogeneity in methods, inclusion criteria, follow-up and reporting of results. Opportunities exist for primary studies assessing the longitudinal HRQoL over the entire course of the diseases to inform clinical practice, economic evaluations and health policy.es_AR
dc.formatapplication/pdf
dc.format.extent1.1 MB
dc.language.isoenges_AR
dc.publisherElsevieres_AR
dc.relationinfo:eu-repo/semantics/altIdentifier/urn/https://www.sciencedirect.com/science/article/pii/S1098301520301807
dc.relationinfo:eu-repo/semantics/altIdentifier/urn/https://www.valueinhealthjournal.com/article/S1098-3015(20)30180-7/fulltext?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1098301520301807%3Fshowall%3Dtrue
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGuillaines_AR
dc.subjectBarré syndromees_AR
dc.subjectMicrocephalyes_AR
dc.subjectZika viruses_AR
dc.subjectHealth-related quality of lifees_AR
dc.subjectSystematic reviewes_AR
dc.titleHealth-related quality of life in neurological disorders most commonly associated with zika-virus infection : a systematic reviewes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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